Autocrine Interleukin-lp Regulates Both Proliferation and Apoptosis in EL4-6.1 Thymoma Cells
نویسندگان
چکیده
We demonstrate here that EL4-6.1 cells, a mouse thymoma that expresses high levels of membrane interleukin (IL)-l receptors, produce IL-IB as an autocrine regulatory factor. Endogenous IL-IB sustains both proliferation and apoptosis: during the exponential phase, it mainly promotes proliferation, while during the plateau phase of cell growth, it induces death by apoptosis. Additionally, we show that exoge-
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